Formulation Of Bcs Class 2 Drugs
Types Of Drug Formulation
Drug carrier systems for solubility enhancement of BCS class II drugs: a critical. The establishment of a suitable formulation layout among various techniques. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor dissolution rate of BCS class II and IV drugs. BCS can be used to flag drugs that should not be tested clini-cally unless appropriate formu-lation strategies are employed (see Figure 1). As an example, a BCS Class II compound, per-meable but relatively insoluble, would likely not be a good clini-cal candidate without the use of enhanced formulation tech. And marketed. Nevertheless, several Class IV drugs do exist (7, 9, 10). Examples include hydrochlorothiazide, taxol, and furosemide. BCS CLASS BOUNDARIES Class boundary parameters (i.e., solubility, permeability, and dissolution) are for easy identification and determination of BCS class (2, 4 11).